This one really requires audio to do it justice, but oh well.
Jessie is this unfortunate soul who was born into a body too hideous for society to accept. She grew up across the street from my dad and still lives across from my grandparents. Apparently she was friends with my dad and his sisters until around middle school, when being a freakish mutant can be damaging to one's social standing.
So they stopped hanging out with her about 45 years ago. But she never got the hint. She still waddles over to my grandparents whenever she sees an extra car or two parked out front. Once I was parked out front of my grandparents with my girlfriend, making out at 11 o'clock at night when she comes shining a flashlight in on us. I think Ojo and Snake have had similar experiences.
Anyway, whenever she pops in on family occasions things get awkward because no one wants her there but everyone is too polite to tell her to go away. (Except for me, I just don't tell her because she's batshit crazy and I'm afraid tipping her the wrong direction could end with one or both of my grandparents being "hobbled".) Eventually she tires of the giant voids in the conversation her presence creates and leaves. Then the jokes start. My dad is by no means alone in the cruel humor directed at this poor wretch. Most of my aunts and uncles have a go, and my grandfather almost never misses a chance. If anything my dad is more tame than most in his zingers. But he always says her name this way, like a narrator revealing some unspeakable horror.